Hidden pharmacological activities of valproic acid: A new insight
Valproic acid (VPA) is an approved drug for managing epileptic seizures, bipolar disorders, and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid (GABA) in the brain through competitive inhibition of GABA transaminase, thus promoting the availability of synaptic GABA and f...
Main Authors: | Dhirendra Singh, Sumeet Gupta, Inderjeet Verma, Mohamed A. Morsy, Anroop B. Nair, Al-Shaimaa F. Ahmed |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-10-01
|
Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332221008040 |
Similar Items
-
Valproic Acid and Breast Cancer: State of the Art in 2021
by: Anna Wawruszak, et al.
Published: (2021-07-01) -
Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation
by: Dong-In Sinn, et al.
Published: (2007-05-01) -
Does Valproic Acid Have Potential in the Treatment of Diabetes Mellitus?
by: Aleksei Rakitin
Published: (2017-06-01) -
HDAC2 Inhibitor Valproic Acid Increases Radiation Sensitivity of Drug-Resistant Melanoma Cells
by: Bhuvanesh Sukhlal Kalal, et al.
Published: (2019-03-01) -
Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts
by: Yingzi eHe, et al.
Published: (2014-11-01)