Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of ketogenesis and ketone metabolism on liver homeost...

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Bibliographic Details
Main Authors: David B. Stagg, Jacob R. Gillingham, Alisa B. Nelson, Justin E. Lengfeld, D. André d’Avignon, Patrycja Puchalska, Peter A. Crawford
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
Mitochondrial redox homeostasis
Hepatic ketogenesis
Liver oxidative metabolism
Glucose metabolism
Metabolomics
Metabolic flux
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001149

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http://www.sciencedirect.com/science/article/pii/S2212877821001149

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