C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

Abstract Background Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of a...

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Bibliographic Details
Main Authors: Jacob C. A. Edvinsson, Karin Warfvinge, Diana N. Krause, Frank W. Blixt, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Format: Article
Language:English
Published: BMC 2019-11-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
Node of Ranvier,
Aδ-fibers
C-fibers
Trigeminal ganglion
CASPR
Online Access:http://link.springer.com/article/10.1186/s10194-019-1055-3

Internet

http://link.springer.com/article/10.1186/s10194-019-1055-3

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