Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations

Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations

In most of cells bradykinin (BK) induces intracellular calcium mobilization. In pancreatic beta cells intracellular calcium is a major signal for insulin secretion. In these cells, glucose metabolism yields intracellular ATP which blocks membrane potassium channels. The membrane depolarizes, voltage...

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Bibliographic Details
Main Author:	A.S. Moura
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2000-09-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	membrane potential pancreatic beta cell bradykinin calcium
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900016

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