Protective Effect of Melatonin Against Mitomycin C-Induced Genotoxic Damage in Peripheral Blood of Rats

Mitomycin C (MMC) generates free radicals when metabolized. We investigated the effect of melatonin against MMC-induced genotoxicity in polychromatic erythrocytes and MMC-induced lipid peroxidation in brain and liver homogenates. Rats (N = 36) were classified into 4 groups: control, melatonin, MMC,...

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Bibliographic Details
Main Authors: S. Ortega-Gutiérrez, M. López-Vicente, F. Lostalé, L. Fuentes-Broto, E. Martínez-Ballarín, J. J. García
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2009/791432