Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

<p>Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with the Wnt receptor Frizzled. Blocking the Dvl PDZ–Frizzled interaction represents a potential approach for cancer treatment, which stimulated the identification of sma...

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Bibliographic Details
Main Authors: N. Kamdem, Y. Roske, D. Kovalskyy, M. O. Platonov, O. Balinskyi, A. Kreuchwig, J. Saupe, L. Fang, A. Diehl, P. Schmieder, G. Krause, J. Rademann, U. Heinemann, W. Birchmeier, H. Oschkinat
Format: Article
Language:English
Published: Copernicus Publications 2021-06-01
Series:Magnetic Resonance
Online Access:https://mr.copernicus.org/articles/2/355/2021/mr-2-355-2021.pdf

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https://mr.copernicus.org/articles/2/355/2021/mr-2-355-2021.pdf

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