Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

Mutations in LRRK2 cause a dominantly inherited form of Parkinson’s disease (PD) and are the most common known genetic determinant of PD. Inhibitor-based therapies targeting LRRK2 have emerged as a key therapeutic strategy in PD; thus, understanding the consequences of inhibiting the normal cellular...

Full description

Bibliographic Details
Main Authors: Mark W. Dodson, Lok K. Leung, Mohiddin Lone, Michael A. Lizzio, Ming Guo
Format: Article
Language:English
Published: The Company of Biologists 2014-12-01
Series:Disease Models & Mechanisms
Subjects:
LRRK2
Lysosome
Parkinson’s disease
Drosophila
Autophagy
Endosomes
Rab7
Rab9
Online Access:http://dmm.biologists.org/content/7/12/1351

Internet

http://dmm.biologists.org/content/7/12/1351

Similar Items