Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The object...

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Bibliographic Details
Main Authors: Nuria DeGregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mònica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer, Enrique Alborch, Ignacio Lizasoain, José Castillo, Antoni Dávalos, Teresa Gasull
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Experimental stroke
Brain damage
Neuroprotection
Apotransferrin
Blood transferrin saturation (TSAT)
Reactive oxygen species (ROS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717308017

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http://www.sciencedirect.com/science/article/pii/S2213231717308017

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