T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment

Abstract Background Early Alzheimer’s disease (AD) diagnosis is vital for development of disease-modifying therapies. Prior to significant brain tissue atrophy, several microstructural changes take place as a result of Alzheimer’s pathology. These include deposition of amyloid, tau and iron, as well...

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Bibliographic Details
Main Authors: Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Hanna K. Isotalus, Serena Dillon, Demitra Tsivos, Risto A. Kauppinen, Elizabeth J. Coulthard
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Magnetic resonance imaging
Alzheimer’s disease
Early diagnosis
Ageing
Hippocampus
T2 relaxometry
Online Access:http://link.springer.com/article/10.1186/s13195-020-00672-9

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http://link.springer.com/article/10.1186/s13195-020-00672-9

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