CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

Abstract Background Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular oxygenation and norm...

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Bibliographic Details
Main Authors: Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib, Margaret Ashcroft
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer & Metabolism
Subjects:
Coiled-coil-helix-coiled-coil-helix domain-containing 4 (CHCHD4)
Hypoxia
HIF-1α
Mitochondria
Respiratory chain
Disulfide relay system
Online Access:http://link.springer.com/article/10.1186/s40170-019-0194-y

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http://link.springer.com/article/10.1186/s40170-019-0194-y

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