The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons.

The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons.

The neurofilament light subunit (NF-L) binds to myosin Va (Myo Va) in neurons but the sites of interaction and functional significance are not clear. We show by deletion analysis that motor domain of Myo Va binds to the NF-L rod domain that forms the NF backbone. Loss of NF-L and Myo Va binding from...

Full description

Bibliographic Details
Main Authors: Mala V Rao, Panaiyur S Mohan, Asok Kumar, Aidong Yuan, Lee Montagna, Jabbar Campbell, Veeranna, Enilza M Espreafico, Jean P Julien, Ralph A Nixon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3040190?pdf=render

Internet

http://europepmc.org/articles/PMC3040190?pdf=render

Similar Items