QSAR-based rational discovery of novel substituted-4′-iminospiro[indoline-3,3′-[1,2,5]thiadiazolidinyl]-2-one 1′,1′-dioxide with potent in vitro anticancer activity

QSAR-based rational discovery of novel substituted-4′-iminospiro[indoline-3,3′-[1,2,5]thiadiazolidinyl]-2-one 1′,1′-dioxide with potent in vitro anticancer activity

Abstract Recent studies have suggested that aldose reductase inhibition preferentially inhibits the growth of cancer cells. However, the investigations of this issue are not many. Novel nine substituted- 4′-iminospiro[indoline-3,3′-[1,2,5] thiadiazolidinyl]-2-one 1′,1′-dioxide derivatives were desig...

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Bibliographic Details
Main Authors: Mohammed A. Khedr, Reem I. Al-Wabli, Maha S. Almutairi, Wafaa A. Zaghary
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Chemistry
Subjects:
QSAR
Conformational rigidification
Molecular docking
Molecular dynamics
In vitro anticancer activity
Online Access:http://link.springer.com/article/10.1186/s13065-019-0520-z

Internet

http://link.springer.com/article/10.1186/s13065-019-0520-z

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