Monomeric bistability and the role of autoloops in gene regulation.

Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with effic...

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Bibliographic Details
Main Authors: Stefanie Widder, Javier Macía, Ricard Solé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2671156?pdf=render