Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.

Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.

A single helicase amino acid substitution, NS3-T249P, has been shown to increase viremia magnitude/mortality in American crows (AMCRs) following West Nile virus (WNV) infection. Lineage/intra-lineage geographic variants exhibit consistent amino acid polymorphisms at this locus; however, the majority...

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Bibliographic Details
Main Authors: Stanley A Langevin, Richard A Bowen, William K Reisen, Christy C Andrade, Wanichaya N Ramey, Payal D Maharaj, Michael Anishchenko, Joan L Kenney, Nisha K Duggal, Hannah Romo, Aloke Kumar Bera, Todd A Sanders, Angela Bosco-Lauth, Janet L Smith, Richard Kuhn, Aaron C Brault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4074097?pdf=render

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http://europepmc.org/articles/PMC4074097?pdf=render

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