A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion

A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion

The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic screen in recombinant inbred mice for quantitative trai...

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Bibliographic Details
Main Authors: Alexandre Picard, Josselin Soyer, Xavier Berney, David Tarussio, Simon Quenneville, Maxime Jan, Eric Grouzmann, Frédéric Burdet, Mark Ibberson, Bernard Thorens
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
genetic screen
glucose sensing
QTL mapping
FGF15
FGF19
hypothalamus
dorsal vagal complex
neuroglucopenia
glucagon secretion
autonomic nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314619

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http://www.sciencedirect.com/science/article/pii/S2211124716314619

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