Synthesis and In Vitro Cytotoxic Properties of Polycarbo-Substituted 4-(Arylamino)quinazolines

Synthesis and In Vitro Cytotoxic Properties of Polycarbo-Substituted 4-(Arylamino)quinazolines

Herein, we describe the synthesis of novel unsymmetrical polycarbo-substituted 4-anilinoquinazolines derived from the 2-aryl-6-bromo-8-iodoquinazolines via one-pot three-step reaction sequences involving initial amination and subsequent double cross-coupling (bis-Suzuki, Sonogashira/Stille or Sonoga...

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Bibliographic Details
Main Authors: Hugues Kamdem Paumo, Tshepiso Jan Makhafola, Malose Jack Mphahlele
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
2-aryl-6-bromo-4-chloro-8-iodoquinazolines
amination
cross-coupling
polycarbo-substituted 4-anilinoquinazolines
cytotoxicity
apoptosis
Online Access:http://www.mdpi.com/1420-3049/21/10/1366

Internet

http://www.mdpi.com/1420-3049/21/10/1366

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