cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE

Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficiency of cGAS or STING in these models ameliorates dis...

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Bibliographic Details
Main Authors: Mona Motwani, Jason McGowan, Jennifer Antonovitch, Kevin MingJie Gao, Zhaozhao Jiang, Shruti Sharma, Gretchen A. Baltus, Kevin M. Nickerson, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
cGAS/STING
SLE
pristane
DNaseI
TLRs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.605930/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.605930/full

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