Nrf2 Ablation Promotes Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress

Nrf2 Ablation Promotes Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress

Introduction. Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that the slow progressive deterioration of AD is associated with oxidative stress...

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Main Authors: Peng Ren, Jingwei Chen, Bingxuan Li, Mengzhou Zhang, Bei Yang, Xiangshen Guo, Ziyuan Chen, Hao Cheng, Pengfei Wang, Shuaibo Wang, Ning Wang, Guohua Zhang, Xu Wu, Dan Ma, Dawei Guan, Rui Zhao
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/3050971

Internet

http://dx.doi.org/10.1155/2020/3050971

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