Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer’s Disease

Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer’s Disease

Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has been specially acknowledged for its functions as a transporter protein of thyroxine and retinol (the latter through bindin...

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Bibliographic Details
Main Authors: Tiago Gião, Joana Saavedra, Ellen Cotrina, Jordi Quintana, Jordi Llop, Gemma Arsequell, Isabel Cardoso
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
transport protein
neuroprotection
blood–brain barrier
alzheimer’s disease
ttr tetrameric stability
amyloid diseases
cerebrospinal fluid protein
angiogenesis
Online Access:https://www.mdpi.com/1422-0067/21/6/2075

Internet

https://www.mdpi.com/1422-0067/21/6/2075

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