Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations

Bioanalytical method for the quantification of the monastrol derivative anticancer candidate lasom 65 in pre-clinical pharmacokinetic investigations

A simple HPLC/UV method was developed for the determination of the anticancer candidate LaSOM 65 in rat plasma. Samples were cleaned by protein precipitation with acetonitrile (recovery > 95%), after which they were subjected to chromatography under the isocratic elution of an acetonitrile:water...

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Bibliographic Details
Main Authors: Bruna G. S. Torres, Flávia D. T. Uchôa, Rômulo F. S. Canto, Allan Crestani, Vera Eifler-Lima, Teresa Dalla Costa
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2014-06-01
Series:Química Nova
Subjects:
LaSOM 65
HPLC
pharmacokinetics.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000300012&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000300012&lng=en&tlng=en

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