De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA

De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA

Background & Aims: Chronic HBV infection cannot be cured by current therapeutics owing to their limited ability to reduce covalently closed circular (ccc)DNA levels in the livers of infected individuals. Therefore, greater understanding of the molecular determinants of cccDNA formation and p...

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Bibliographic Details
Main Authors: Thomas Tu, Benno Zehnder, Bingqian Qu, Stephan Urban
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:JHEP Reports
Subjects:
Covalently closed circular DNA
Myrcludex B
Bulevirtide
Hepcludex
HBV persistence
Core protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555920301294

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http://www.sciencedirect.com/science/article/pii/S2589555920301294

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