Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats

Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats

It is well known that bacterial lipopolysaccharides (LPS) both increases proinflammatory cytokines and produces sickness behavior, including fatigue and anhedonia (i.e., the inability to experience pleasure). Previously, we have shown that intraperitoneally (i.p.) administered LPS increased extracel...

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Bibliographic Details
Main Authors: Gerdien A. H. Korte-Bouws, Floor van Heesch, Koen G. C. Westphal, Lisa M. J. Ankersmit, Edwin M. van Oosten, Onur Güntürkün, S. Mechiel Korte
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Pharmaceuticals
Subjects:
lipopolysaccharide
proinflammatory cytokines
serotonin transporter
Slc6a41
metabolism
microdialysis
medial prefrontal cortex
nucleus accumbens
Online Access:http://www.mdpi.com/1424-8247/11/3/66

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http://www.mdpi.com/1424-8247/11/3/66

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