Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing HSP70 peptide

Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing HSP70 peptide

Antigen-specific regulatory T cells (Tregs) directed at self-antigens are difficult to study since suitable specific tools to isolate and characterize these cells are lacking. A T cell receptor (TCR)-transgenic mouse would generate possibilities to study such antigen-specific T cells. As was shown p...

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Bibliographic Details
Main Authors: Manon AA Jansen, Martijn JC Van Herwijnen, Peter JS van Kooten, Aad eHoek, Ruurd eVan Der Zee, Willem eVan Eden, Femke eBroere
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Immunology
Subjects:
Autoimmunity
regulatory T cells
Transgenic mouse
heat shock protein 70
hybridoma
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00090/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00090/full

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