c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells

c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells

<p>Abstract</p> <p>Background</p> <p>Endothelin-1 (ET-1) is elevated and participates in the regulation of several brain inflammatory disorders. The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the upregulation of cy...

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Bibliographic Details
Main Authors: Hsieh Hsi-Lung, Lin Chih-Chung, Chan Hui-Ju, Yang Caleb M, Yang Chuen-Mao
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/9/1/152

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