The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.

The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.

The sensitivity of only a few tumors to anti-epidermal growth factor receptor EGFR tyrosine kinase inhibitors (TKIs) can be explained by the presence of EGFR tyrosine kinase (TK) domain mutations. In addition, such mutations were rarely found in tumor types other than lung, such as pancreatic and he...

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Bibliographic Details
Main Authors: Xiaofei Chang, Eugene Izumchenko, Luisa M Solis, Myoung Sook Kim, Aditi Chatterjee, Shizhang Ling, Constance L Monitto, Paul M Harari, Manuel Hidalgo, Steve N Goodman, Ignacio I Wistuba, Atul Bedi, David Sidransky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3729565?pdf=render

Internet

http://europepmc.org/articles/PMC3729565?pdf=render

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