Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells

Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells

Background/Aims: Resistance of leukemia stem cells (LSCs) to chemotherapy in patients with acute myeloid leukemia (AML) causes relapse of disease. Hedgehog (Hh) signaling plays a critical role in the maintenance and differentiation of cancer stem cells. Yet its role in AML remains controversial. The...

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Bibliographic Details
Main Authors: Bing Long, Le-Xun Wang, Fei-Meng Zheng, Shu-Ping Lai, Duo-Rong Xu, Yuan Hu, Dong-Jun Lin, Xiang-Zhong Zhang, Lin Dong, Zi-Jie Long, Xiu-Zhen Tong, Quentin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Acute myeloid leukemia
Leukemia progenitor cell
Hedgehog signaling pathway
GLI1
Small-molecule inhibitor
GANT61
Online Access:http://www.karger.com/Article/FullText/443075

Internet

http://www.karger.com/Article/FullText/443075

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