Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory

Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory

The benefits of anti-cancer agents extend beyond direct tumor killing. One aspect of cell death is the potential to release antigens that initiate adaptive immune responses. Here, a diffusion enhanced formulation, INT230-6, containing potent anti-cancer cytotoxic agents, was administered intratumora...

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Bibliographic Details
Main Authors: Anja C. Bloom, Lewis H. Bender, Shweta Tiwary, Lise Pasquet, Katharine Clark, Tianbo Jiang, Zheng Xia, Aizea Morales-Kastresana, Jennifer C. Jones, Ian Walters, Masaki Terabe, Jay A. Berzofsky
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:OncoImmunology
Subjects:
endogenous vaccine
tumor model
anticancer agent
t cells
intratumoral delivery
pd-1
chemotherapy
combination therapy
immunogenic cell death
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1625687

Internet

http://dx.doi.org/10.1080/2162402X.2019.1625687

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