IFN-γ production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner.

IFN-γ production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner.

Dengue is a mosquito-borne disease caused by one of four serotypes of Dengue virus (DENV-1-4). Severe dengue infection in humans is characterized by thrombocytopenia, increased vascular permeability, hemorrhage and shock. However, there is little information about host response to DENV infection. He...

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Bibliographic Details
Main Authors: Caio T Fagundes, Vivian V Costa, Daniel Cisalpino, Flávio A Amaral, Patrícia R S Souza, Rafael S Souza, Bernhard Ryffel, Leda Q Vieira, Tarcília A Silva, Alena Atrasheuskaya, George Ignatyev, Lirlândia P Sousa, Danielle G Souza, Mauro M Teixeira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3243710?pdf=render

Internet

http://europepmc.org/articles/PMC3243710?pdf=render

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