The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice

The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice

Abstract Background Osteoclasts are key determinant cellular components implicated in the development and progression of disorders driven by bone damage. Herein, we studied the upshot of T007, an antagonist of peroxisome proliferator-activated receptor-gamma (PPARγ), on osteoclastogenesis using cell...

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Bibliographic Details
Main Authors: Xiang Li, Lei Ning, Jianjun Ma, Ziang Xie, Xiangde Zhao, Gangliang Wang, Xinyu Wan, Pengcheng Qiu, Teng Yao, Haoming Wang, Shunwu Fan, Shuanglin Wan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Subjects:
Osteoclasts
T007
Peroxisome proliferator-activated receptor-gamma
Osteoporosis
Receptor activator of nuclear factor-κB ligand
Online Access:http://link.springer.com/article/10.1186/s12964-019-0442-3

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http://link.springer.com/article/10.1186/s12964-019-0442-3

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