Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress

Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress

Although chemotherapeutics can be highly effective at targeting malignancies, their ability to trigger cardiovascular morbidity is clinically significant. Chemotherapy can adversely affect cardiovascular physiology, resulting in the development of cardiomyopathy, heart failure and microvascular defe...

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Bibliographic Details
Main Authors: Nabeel Quryshi, Laura E. Norwood Toro, Karima Ait-Aissa, Amanda Kong, Andreas M. Beyer
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac oncology
mtDNA damage
telomerase
telomerase activity
heart failure
Online Access:http://www.mdpi.com/1422-0067/19/3/797

Internet

http://www.mdpi.com/1422-0067/19/3/797

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