Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations

Combination of Proteasome and Histone Deacetylase Inhibitors Overcomes the Impact of Gain-of-Function p53 Mutations

Mutations in the “guardian of the genome” TP53 predominate in solid tumors. In addition to loss of tumor suppressor activity, a specific subset of missense mutations confers additional oncogenic properties. These “gain-of-function” (GOF) mutations portend poor prognosis across cancer types regardles...

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Bibliographic Details
Main Authors: Xiangbing Meng, Shujie Yang, Yujun Li, Yiyang Li, Eric J. Devor, Jianling Bi, Xinhao Wang, Shaikamjad Umesalma, Dawn E. Quelle, William H. Thiel, Kristina W. Thiel, Kimberly K. Leslie
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2018/3810108

Internet

http://dx.doi.org/10.1155/2018/3810108

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