Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution.

Volume replacement strategies do not impair the binding of dabigatran to idarucizumab: Porcine model of hemodilution.

<h4>Background</h4>Idarucizumab is a humanized Fab fragment that specifically reverses dabigatran anticoagulation. In trauma, volume expanders are used for resuscitation to compensate for blood loss and hemorrhagic shock, but it is unknown whether volume expanders influence the binding o...

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Bibliographic Details
Main Authors: Oliver Grottke, Joanne van Ryn, Christian Zentai, Guanfa Gan, Markus Honickel, Rolf Rossaint, Hugo Ten Cate, Henri M H Spronk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209350

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https://doi.org/10.1371/journal.pone.0209350

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