Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery

Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery

Perioperative neurocognitive disorder (PND) leads to progressive deterioration of cognitive function, especially in aged patients. Demyelination is closely associated with cognitive dysfunction. However, the relationship between PND and demyelination remains unclear. Here we showed that demyelinatio...

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Bibliographic Details
Main Authors: Wensi Wu, Xiaojun Zhang, Jiaxin Zhou, Hongmei Yang, Junjun Chen, Le Zhao, Junying Zhong, Wei-jye Lin, Zhi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
perioperative neurocognitive disorder
clemastine
neuroinflammation
wnt/β-catenin signaling
remyelination
synaptic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.738590/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.738590/full

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