Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma

Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma

Immunotherapy clinical trials targeting the programmed-death ligand axis (PD-1/PD-L1) show that most head and neck squamous cell carcinoma (HNSCC) patients are resistant to PD-1/PD-L1 inhibition. We investigated whether local radiation to the tumor can transform the immune landscape and render poorl...

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Bibliographic Details
Main Authors: Ayman Oweida, Shelby Lennon, Dylan Calame, Sean Korpela, Shilpa Bhatia, Jaspreet Sharma, Caleb Graham, David Binder, Natalie Serkova, David Raben, Lynn Heasley, Eric Clambey, Raphael Nemenoff, Sana D. Karam
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
radiotherapy
head and neck cancer
immune checkpoint inhibitors
pd-l1
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1356153

Internet

http://dx.doi.org/10.1080/2162402X.2017.1356153

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