Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Different cells of the tumour microenvironment in HBV-associated human hepatocellular carcinoma (HCC) interact to promote tumour immunity. Here the authors use single cell RNA sequencing to identify TIGIT-NECTIN2 as a pathway by which tumour-associated macrophages reduce intratumour T cell activatio...

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Bibliographic Details
Main Authors: Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24010-1

Internet

https://doi.org/10.1038/s41467-021-24010-1

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