The Effects of Selective Inhibition of Histone Deacetylase 1 and 3 in Huntington’s Disease Mice

The Effects of Selective Inhibition of Histone Deacetylase 1 and 3 in Huntington’s Disease Mice

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by a late clinical onset of psychiatric, cognitive, and motor symptoms. Transcriptional dysregulation is an early and central disease mechanism which is accompanied by epigenetic alterations in HD. Previous st...

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Bibliographic Details
Main Authors: Katharina Hecklau, Susanne Mueller, Stefan Paul Koch, Mustafa Hussain Mehkary, Busra Kilic, Christoph Harms, Philipp Boehm-Sturm, Ferah Yildirim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HDAC inhibition
RGFP109
transcriptional dysregulation
Huntington’s disease
R6/1 mouse model
volumetric MRI
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.616886/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.616886/full

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