Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Although considerable progress has been made in elucidating the etiology of the disease, the prognosis for individuals diagnosed with HNSCC remains poor, underscoring the need for development of additional treat...

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Bibliographic Details
Main Authors: Jeffrey M Schafer, Diane E Peters, Thomas Morley, Shihui Liu, Alfredo A Molinolo, Stephen H Leppla, Thomas H Bugge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3105081?pdf=render

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http://europepmc.org/articles/PMC3105081?pdf=render

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