Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study

Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study

Potential of nanoscale triazine based dendritic macromolecules G1, G2 and G3 as solubility enhancers of drug was investigated. Effect of pH, concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied. G3 dendrimer was further exploited as carrier for...

Full description

Bibliographic Details
Main Authors: Pravinkumar M. Patel, Rinkesh Patel, Devang Wadia, Rajni M. Patel
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Triazine based dendrimer
Ketoprofen
Drug carrier
Cytotoxicity
Hemolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087615000288
id doaj-f967baccb2fa43b38e60b43a87f5aa06
record_format Article
spelling doaj-f967baccb2fa43b38e60b43a87f5aa062020-11-24T22:19:05ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-07-0110430631310.1016/j.ajps.2015.04.002Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity studyPravinkumar M. Patel0Rinkesh Patel1Devang Wadia2Rajni M. Patel3Industrial Chemistry Department, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University, Vallabh Vidhyanagar, Gujarat, IndiaIndustrial Chemistry Department, V.P. & R.P.T.P. Science College, Affiliated to Sardar Patel University, Vallabh Vidhyanagar, Gujarat, IndiaNirlife Healthcare Division, Nirma Limited, Ahmedabad, Gujarat, IndiaP. D. Patel Institute of Pure and Applied Sciences, Charusat University, Changa, Gujarat, IndiaPotential of nanoscale triazine based dendritic macromolecules G1, G2 and G3 as solubility enhancers of drug was investigated. Effect of pH, concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied. G3 dendrimer was further exploited as carrier for sustained release. Ketoprofen was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared spectroscopy. Sustained release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free ketoprofen. Hemolytic potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer.http://www.sciencedirect.com/science/article/pii/S1818087615000288Triazine based dendrimerKetoprofenDrug carrierCytotoxicityHemolysis
collection DOAJ
language English
format Article
sources DOAJ
author Pravinkumar M. Patel
Rinkesh Patel
Devang Wadia
Rajni M. Patel
spellingShingle Pravinkumar M. Patel
Rinkesh Patel
Devang Wadia
Rajni M. Patel
Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
Asian Journal of Pharmaceutical Sciences
Triazine based dendrimer
Ketoprofen
Drug carrier
Cytotoxicity
Hemolysis
author_facet Pravinkumar M. Patel
Rinkesh Patel
Devang Wadia
Rajni M. Patel
author_sort Pravinkumar M. Patel
title Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
title_short Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
title_full Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
title_fullStr Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
title_full_unstemmed Dendritic macromolecules as nano-scale drug carriers: Phase solubility, in vitro drug release, hemolysis and cytotoxicity study
title_sort dendritic macromolecules as nano-scale drug carriers: phase solubility, in vitro drug release, hemolysis and cytotoxicity study
publisher Elsevier
series Asian Journal of Pharmaceutical Sciences
issn 1818-0876
publishDate 2015-07-01
description Potential of nanoscale triazine based dendritic macromolecules G1, G2 and G3 as solubility enhancers of drug was investigated. Effect of pH, concentration and generation of synthesized dendritic macromolecules on solubility of ketoprofen was studied. G3 dendrimer was further exploited as carrier for sustained release. Ketoprofen was encapsulated by inclusion complex method and also characterized by Flourier Transform Infrared spectroscopy. Sustained release study of ketoprofen from ketoprofen loaded dendrimer was carried out and compared with free ketoprofen. Hemolytic potential and Cytotoxicity assay using A-549 lung cancer cell lines revealed that synthesized triazine based dendritic macromolecules having more potential that commercially available PAMAM dendrimer.
topic Triazine based dendrimer
Ketoprofen
Drug carrier
Cytotoxicity
Hemolysis
url http://www.sciencedirect.com/science/article/pii/S1818087615000288
work_keys_str_mv AT pravinkumarmpatel dendriticmacromoleculesasnanoscaledrugcarriersphasesolubilityinvitrodrugreleasehemolysisandcytotoxicitystudy
AT rinkeshpatel dendriticmacromoleculesasnanoscaledrugcarriersphasesolubilityinvitrodrugreleasehemolysisandcytotoxicitystudy
AT devangwadia dendriticmacromoleculesasnanoscaledrugcarriersphasesolubilityinvitrodrugreleasehemolysisandcytotoxicitystudy
AT rajnimpatel dendriticmacromoleculesasnanoscaledrugcarriersphasesolubilityinvitrodrugreleasehemolysisandcytotoxicitystudy
_version_ 1725780248165875712

Similar Items