A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome

Metabolic syndrome is characterized by complex phenotypes that increases the risk of cardiovascular disease and type 2 diabetes. Here the authors’ integrative network analysis suggests BTK inhibitor ibrutinib to be a promising treatment through its obesity-associated inflammation lowering effect.

Bibliographic Details
Main Authors: Karla Misselbeck, Silvia Parolo, Francesca Lorenzini, Valeria Savoca, Lorena Leonardelli, Pranami Bora, Melissa J. Morine, Maria Caterina Mione, Enrico Domenici, Corrado Priami
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13208-z