Investigation of the extremely weak interaction between the Japanese encephalitis virus and CLEC5A using a multivalent-interaction-enhancement sensing electrode

Investigation of the extremely weak interaction between the Japanese encephalitis virus and CLEC5A using a multivalent-interaction-enhancement sensing electrode

A lectin receptor, CLEC5A, plays an important role in the pathogenic mechanism of dengue virus (DV). The binding affinity between the DV envelope E-protein and CLEC5A is extremely weak and not easily detected using traditional methods, such as ELISA, making the characterization of the binding epitop...

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Bibliographic Details
Main Authors: Yen-Ting Tung, Jian-Jong Liang, Hsiao-Ting Feng, Ruei-Ning Jhang, Shie-Liang Hsieh, Yi-Ling Lin, Gou-Jen Wang
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Biosensors and Bioelectronics: X
Subjects:
JEV
Gain-or-loss glycosylation
Multivalent interactions
Nano-hemisphere array biosensor
Online Access:http://www.sciencedirect.com/science/article/pii/S2590137019300147

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http://www.sciencedirect.com/science/article/pii/S2590137019300147

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