mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

Background and purpose: Mammalian target of rapamycin (mTOR) pathway signaling governs cellular responses to hypoxia and inflammation including induction of autophagy and cell survival. Cerebral palsy (CP) is a neurodevelopmental disorder linked to hypoxic and inflammatory brain injury however, a ro...

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Bibliographic Details
Main Authors: Isha N. Srivastava, Jona Shperdheja, Marianna Baybis, Tanya Ferguson, Peter B. Crino
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neurobiology of Disease
Subjects:
Cerebral palsy
mTOR
Rapamycin
Cell death
Autophagy
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300619

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http://www.sciencedirect.com/science/article/pii/S0969996115300619

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