A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy

A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy

Antibody directed enzyme prodrug therapy (ADEPT) utilizing β-lactamase is a promising treatment strategy to enhance the therapeutic effect and safety of cytotoxic agents. In this method, a conjugate (antibody-β-lactamase fusion protein) is employed to precisely activate nontoxic cephalosporin prodr...

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Bibliographic Details
Main Authors: Hao Wang, Xiao-Liang Zhou, Wei Long, Jin-Jian Liu, Fei-Yue Fan
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
antibody directed enzyme prodrug therapy
RGD4C
β-lactamase
targeting
Online Access:http://www.mdpi.com/1422-0067/16/5/9625

Internet

http://www.mdpi.com/1422-0067/16/5/9625

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