Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure. Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (Cysltr1), which protects from inflammation and oxidative stres...

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Bibliographic Details
Main Authors: Shiyun Pu, Qinhui Liu, Yanping Li, Rui Li, Tong Wu, Zijing Zhang, Cuiyuan Huang, Xuping Yang, Jinhan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
montelukast
acetaminophen
cysteinyl leukotriene receptor 1
glutathione
JNK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01070/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01070/full

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