The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin

The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin

Type II topoisomerase enzymes are essential for resolving DNA topology problems arising through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of which (TOP2A) accumulates on chromatin during mitosis. Moreover, TOP2A targets the mitotic centromere during prophase, pe...

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Bibliographic Details
Main Authors: Melissa Antoniou-Kourounioti, Michael L. Mimmack, Andrew C.G. Porter, Christine J. Farr
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
topoisomerase II alpha
centromere
mitosis
chromosome
C-terminal domain
post-translational modification
SUMO
phosphorylation
Online Access:http://www.mdpi.com/1422-0067/20/5/1238

Internet

http://www.mdpi.com/1422-0067/20/5/1238

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