Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

XD14 is a 4-acyl pyrrole derivative, which was discovered by a high-throughput virtual screening experiment. XD14 inhibits bromodomain and extra-terminal domain (BET) proteins (BRD2, BRD3, BRD4 and BRDT) and consequently suppresses cell proliferation. In this study, metabolic profiling reveals the m...

Full description

Bibliographic Details
Main Authors:	Daqiang Pan, Michel Kather, Lucas Willmann, Manuel Schlimpert, Christoph Bauer, Simon Lagies, Karin Schmidtkunz, Steffen U. Eisenhardt, Manfred Jung, Stefan Günther, Bernd Kammerer
Format:	Article
Language:	English
Published:	MDPI AG 2016-10-01
Series:	International Journal of Molecular Sciences
Subjects:	XD14 4-acyl pyrrole derivative Michigan Cancer Foundation-7 (MCF-7) GC-MS metabolic profiling cancer therapy BRD-related tumors
Online Access:	http://www.mdpi.com/1422-0067/17/10/1772

Similar Items

Investigation the Effect of the Exposure Time of Docetaxel on MCF-7 Cell Line: An In-Vitro Assessment
by: Ali Ebrahimifard, et al.
Published: (2015-10-01)

Magnetic nanoparticles sensitize MCF-7 breast cancer cells to doxorubicin-induced apoptosis
by: Aljarrah Khaled, et al.
Published: (2012-04-01)

The Effect of Chrysin Nanoparticles in Preventing the Growth of Mcf-7 Cancer Cells
by: M Norouzi, et al.
Published: (2018-10-01)

A Bottom-Up Synthesis Approach to Silver Nanoparticles Induces Anti-Proliferative and Apoptotic Activities Against MCF-7, MCF-7/TAMR-1 and MCF-10A Human Breast Cell Lines
by: Nurul Izzati Zulkifli, et al.
Published: (2020-09-01)

Study of anti-cancer effects of Curcumin; formulation of Curcumin-loaded nano carrier and its toxicity effect on MCF-7 Cell line.
by: masoud zare shehneh, et al.
Published: (2019-05-01)

Effects of HIF-2α on Biological Function of Breast Cancer MCF-7 Cells
by: LIU Yuqiong, et al.
Published: (2018-10-01)

Avoiding the Interference of Doxorubicin with MTT Measurements on the MCF-7 Breast Cancer Cell Line
by: Carla Luis, et al.
Published: (2019-04-01)

Comparison of the Effect of Hydro Alcoholic and Aqueous Extract Aloe Vera on the Proliferation of MCF7
by: Leila Zarei *, et al.
Published: (2019-10-01)

Comparison of Anticancer Activity of <i>Dorycnium pentaphyllum</i> Extract on MCF-7 and MCF-12A Cell Line: Correlation with Invasion and Adhesion
by: Gözde Koygun, et al.
Published: (2021-04-01)

Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model
by: Frank J. Gonzalez, et al.
Published: (2013-08-01)

Insulin stimulated MCF7 breast cancer cells: Proteome dataset
by: Hetal A. Sarvaiya, et al.
Published: (2016-12-01)

Efeitos do tratamento com selênio no crescimento e marcas epigenéticas de células de adenocarcinoma mamário humano MCF-7
by: Juliana Xavier de Miranda
Published: (2012)

Efeitos do tratamento com selênio no crescimento e marcas epigenéticas de células de adenocarcinoma mamário humano MCF-7
by: Miranda, Juliana Xavier de
Published: (2012)

Oleuropein inhibits tumour growth and metastases dissemination in ovariectomised nude mice with MCF-7 human breast tumour xenografts
by: Maria Vittoria Sepporta, et al.
Published: (2014-05-01)

Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line
by: Nanda Ayu Puspita, et al.
Published: (2017-03-01)

The Evaluation of Antioxidant and Anticancer Activity of Alfalfa Extract on MCF7 Cell Line
by: Babak Babakhani, et al.
Published: (2019-01-01)

MCF-7 and its Multidrug Resistant Variant MCF-7/ADR Overcome TNF Cytotoxicity through Prevention of Reactive Oxygen Species Accumulation
by: Morteza Ghandadi, et al.
Published: (2019-06-01)

Evaluation of the effect of amygdalin on survivin gene expression in MCF-7 breast cancer cell line
by: Shahrokhiyan Iman, et al.
Published: (2018-01-01)

Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers
by: Sarvaiya, Hetal Abhijeet
Published: (2014)

Mitochondrial and caspase pathways are involved in the induction of apoptosis by nardosinen in MCF-7 breast cancer cell line
by: Amirhosein Shahali, et al.
Published: (2018-01-01)

Flavone constituents of Phlomis bruguieri Desf. with cytotoxic activity against MCF-7 breast cancer cells
by: Seyed Ebrahim Sajjadi, et al.
Published: (2018-01-01)

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells
by: Mahmoud Hasan, et al.
Published: (2020-04-01)

Evaluation of Pharmacological Effective Concentrations of Aspirin with/without Radiotherapy on MCF-7Breast Cancer Cell Line
by: Negin Farhad, et al.
Published: (2018-07-01)

Efficacy of Combining 3-Bromopyruvate with Fenofibrate in Killing the Human Breast Cancer Cell Line MCF-7

Effect of Allicin on Tamoxifen-sensitive MCF-7 Breast Cancer Cells
by: P Rahimi-Moghaddam, et al.
Published: (2015-05-01)

Ctotoxic and apoptogenic effects of Perovskia abrotanoides flower extract on MCF-7 and HeLa cell lines
by: Mohamad Ali Geryani, et al.
Published: (2016-06-01)

Combination of salermide and Cholera Toxin B induce apoptosis in MCF-7 but not in MRC-5 cell lines
by: Mohammad Reza Salahshoor, et al.
Published: (2013-01-01)

Crystal structure of bis[4-(1H-pyrrol-1-yl)phenyl] ferrocene-1,1′-dicarboxylate: a potential chemotherapeutic drug
by: Wanda I. Pérez, et al.
Published: (2015-05-01)

Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells
by: Tuğba Alarcon Martinez, et al.
Published: (2018-05-01)

Investigation of Cadmium Chloride Cytotoxic Effect in MCF-7 Breast Cancer Cell Line
by: Ali Khojastehfar, et al.
Published: (2014-10-01)

The Study of Apoptotic Effect of p-Coumaric Acid on Breast Cancer Cells MCF-7
by: M Kolahi, et al.
Published: (2016-06-01)

Gynura procumbens Prevents Chemoresistance through Inhibition MDR1 Expression on MCF-7 Breast Cancer Cell Line and Sensitizes the Cells to Doxorubicin
by: Nunuk Aries Nurulita, et al.
Published: (2012-06-01)

Augmentation of anti-proliferative, pro-apoptotic and oxidant profiles induced by piceatannol in human breast carcinoma MCF-7 cells using zein nanostructures
by: Mardi M. Algandaby, et al.
Published: (2021-06-01)

Effect of Stachys setifera essential oil on human breast cancer MCF-7 cells line
by: Amir Shirzad, et al.
Published: (2020-03-01)

Investigating Potential Bioactive Compounds from Rhodococcus and Their Effects on MCF7 Breast Cancer Cells
by: Crabtree, Megan N
Published: (2013)

Cytotoxic and Antiproliferative Effects of Methanolic Extract of Lavandula Angustifolia on MCF-7 Breast Cancer Cell Line
by: Mitra Javanmardi, et al.
Published: (2021-03-01)

Anti-proliferative and Apoptotic Effect of Tetrahydrobenzo[h]quinoline on MCF-7 Human Breast Cancer Cell
by: Ahagh, M.H, et al.
Published: (2022)

Recombinant Human erythropoietin reduces viability of MCF-7 breast cancer cells from 3D culture without caspase activation
by: Hareth Y. ShujaaEdin, et al.
Published: (2021-04-01)

Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line
by: Seyed Hadi Mousavi, et al.
Published: (2015-10-01)

Targeted Fluoromagnetic Nanoparticles for Imaging of Breast Cancer MCF-7 Cells
by: Javid Shahbazi, et al.
Published: (2013-02-01)