Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

XD14 is a 4-acyl pyrrole derivative, which was discovered by a high-throughput virtual screening experiment. XD14 inhibits bromodomain and extra-terminal domain (BET) proteins (BRD2, BRD3, BRD4 and BRDT) and consequently suppresses cell proliferation. In this study, metabolic profiling reveals the m...

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Bibliographic Details
Main Authors: Daqiang Pan, Michel Kather, Lucas Willmann, Manuel Schlimpert, Christoph Bauer, Simon Lagies, Karin Schmidtkunz, Steffen U. Eisenhardt, Manfred Jung, Stefan Günther, Bernd Kammerer
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
XD14
4-acyl pyrrole derivative
Michigan Cancer Foundation-7 (MCF-7)
GC-MS
metabolic profiling
cancer therapy
BRD-related tumors
Online Access:http://www.mdpi.com/1422-0067/17/10/1772

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http://www.mdpi.com/1422-0067/17/10/1772

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