Susceptibility of different hepatitis B virus isolates to interferon-alpha in a mouse model based on hydrodynamic injection.

Susceptibility of different hepatitis B virus isolates to interferon-alpha in a mouse model based on hydrodynamic injection.

Interferon alpha (IFN-α) is commonly used for the treatment of chronic hepatitis B (CHB) patients. Many factors including viral genetics may determine the outcome of IFN-α therapy. In this study, we tested whether the expression of IFN-α directly in the liver inhibits HBV gene expression and replica...

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Bibliographic Details
Main Authors: Jingjiao Song, Yun Zhou, Sheng Li, Baoju Wang, Xin Zheng, Jun Wu, Kathrin Gibbert, Ulf Dittmer, Mengji Lu, Dongliang Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3950299?pdf=render

Internet

http://europepmc.org/articles/PMC3950299?pdf=render

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