Functional Properties of Human NMDA Receptors Associated with Epilepsy-Related Mutations of GluN2A Subunit

Functional Properties of Human NMDA Receptors Associated with Epilepsy-Related Mutations of GluN2A Subunit

Genetic variants of the glutamate activated N-methyl-D-aspartate (NMDA) receptor (NMDAR) subunit GluN2A are associated with the hyperexcitable states manifested by epileptic seizures and interictal discharges in patients with disorders of the epilepsy-aphasia spectrum (EAS). The variants found in sp...

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Bibliographic Details
Main Authors: Dmitry A. Sibarov, Nadine Bruneau, Sergei M. Antonov, Pierre Szepetowski, Nail Burnashev, Rashid Giniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GRIN2A
GluN2A
epilepsy
NMDA receptors
genetic variants
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00155/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00155/full

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