Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis.

Antigen presenting cells (APCs) play an important role in arthritis and APC specific gene therapeutic targeting will enable intracellular modulation of cell activity. Viral mediated overexpression is a potent approach to achieve adequate transgene expression levels and lentivirus (LV) is useful for...

Full description

Bibliographic Details
Main Authors:	Ben T van den Brand, Eline A Vermeij, Claire E J Waterborg, Onno J Arntz, Michael Kracht, Miranda B Bennink, Wim B van den Berg, Fons A J van de Loo
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23390530/?tool=EBI

Similar Items

In Vivo Molecular Imaging of Cathepsin and Matrix Metalloproteinase Activity Discriminates between Arthritic and Osteoarthritic Processes in Mice
by: Eline A. Vermeij, et al.
Published: (2014-01-01)

Lentiviral vectors transduce lung stem cells without disrupting plasticity
by: Ashley L. Cooney, et al.
Published: (2021-09-01)

Preferential lentiviral targeting of astrocytes in the central nervous system.
by: Michael Fassler, et al.
Published: (2013-01-01)

Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo.
by: Séverine Ciré, et al.
Published: (2014-01-01)

DNA Methylation and Histone Modifications Are the Molecular Lock in Lentivirally Transduced Hematopoietic Progenitor Cells
by: Siew Ching Ngai, et al.
Published: (2015-01-01)

Production of Class II MHC Proteins in Lentiviral Vector-Transduced HEK-293T Cells for Tetramer Staining Reagents
by: Altman, J.D, et al.
Published: (2021)

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis
by: Niels A. J. Cremers, et al.
Published: (2017-09-01)

Gas Damping in Capacitive MEMS Transducers in the Free Molecular Flow Regime
by: Boris A. Boom, et al.
Published: (2021-04-01)

Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells
by: Barbara S. Paugh, et al.
Published: (2021-01-01)

Lentiviral Hematopoietic Stem Cell Gene Therapy Corrects Murine Pompe Disease
by: Merel Stok, et al.
Published: (2020-06-01)

Stromal cells of the mouse spleen
by: Joke MM Den Haan, et al.
Published: (2012-07-01)

The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis.
by: Eline A Vermeij, et al.
Published: (2015-01-01)

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
by: Claire E. J. Waterborg, et al.
Published: (2018-04-01)

Design of a titering assay for lentiviral vectors utilizing direct extraction of DNA from transduced cells in microtiter plates
by: Michele E Murphy, et al.
Published: (2016-01-01)

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34+ Cells Correlates With In Vivo Vector Copy Number
by: Naoya Uchida, et al.
Published: (2013-01-01)

Characterisation of lentiviral Vpr function and mechanism
by: Van Tulleken, C. R.
Published: (2017)

Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
by: Rocío Mato-Basalo, et al.
Published: (2021-03-01)

Bicistronic lentiviral vector corrects β-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts
by: Audrey Arfi, et al.
Published: (2005-11-01)

The role of TLR2 in the host response to pneumococcal pneumonia in absence of the spleen
by: Lammers Adriana J J, et al.
Published: (2012-06-01)

Polyarteritis nodosa of the spleen
by: M Smets, et al.
Published: (2010-03-01)

Failure to detect functional neutrophil B helper cells in the human spleen.
by: Sietse Quirijn Nagelkerke, et al.
Published: (2014-01-01)

Dendritic cell nediated inhibition of lentiviral infection
by: Drake A, et al.
Published: (2012-09-01)

In Vivo Imaging of Engraftment and Enrichment of Lentiviral Transduced Hematopoietic Bone Marrow Cells Under MGMT-P140K Mediated Selection
by: Lin, Yuan
Published: (2011)

Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β.
by: Bartijn C H Pieters, et al.
Published: (2015-01-01)

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants
by: Edward JD Greenwood, et al.
Published: (2016-09-01)

Overexpression of thioredoxin in islets transduced by a lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice
by: Sytwu Huey-Kang, et al.
Published: (2009-08-01)

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector
by: Vreugdenhil Erno, et al.
Published: (2010-07-01)

Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing
by: Juan Fafián-Labora, et al.
Published: (2020-01-01)

The Study of Zen Poems During Lý and Trần Dynasty in Vietnam
by: TRAN THI THANH VAN, et al.
Published: (2014)

Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages.
by: Yannick Morias, et al.
Published: (2015-05-01)

Lentiviral vectors for gene therapy
by: Knight, S. B.
Published: (2012)

Lentiviral vectors for treatment of haemophilia
by: Ward, N. J.
Published: (2010)

A Distinct Subset of Highly Proliferative and Lentiviral Vector (LV)-Transducible NK Cells Define a Readily Engineered Subset for Adoptive Cellular Therapy
by: Rafijul Bari, et al.
Published: (2019-08-01)

Lentivirally transduced dendritic cells over-expressing IL-4, IL-12 : effects on RSV and allergen induced airway inflammation and changes in lung function
by: Peters, Nina Katharina
Published: (2006)

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.
by: Claire E J Waterborg, et al.
Published: (2018-01-01)

The Ly-49 family of natural killer cell receptors
by: Brennan, John A.
Published: (2009)

The Ly-49 family of natural killer cell receptors
by: Brennan, John A.
Published: (2009)

Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity
by: Onno J. Arntz, et al.
Published: (2018-10-01)

An optimized method for plasma extracellular vesicles isolation to exclude the copresence of biological drugs and plasma proteins which impairs their biological characterization.
by: Onno J Arntz, et al.
Published: (2020-01-01)

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development.
by: Jessica Filtjens, et al.
Published: (2014-01-01)