Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis.

Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis.

Antigen presenting cells (APCs) play an important role in arthritis and APC specific gene therapeutic targeting will enable intracellular modulation of cell activity. Viral mediated overexpression is a potent approach to achieve adequate transgene expression levels and lentivirus (LV) is useful for...

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Bibliographic Details
Main Authors: Ben T van den Brand, Eline A Vermeij, Claire E J Waterborg, Onno J Arntz, Michael Kracht, Miranda B Bennink, Wim B van den Berg, Fons A J van de Loo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23390530/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23390530/?tool=EBI

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